Further structure–activity relationships study of substituted dithiolethiones as glutathione‑inducing neuroprotective agents

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Further structure–activity relationships study of substituted dithiolethiones as glutathione‑inducing neuroprotective agents

title: Further structure–activity relationships study of substituted dithiolethiones as glutathione‑inducing neuroprotective agents

creator: Brown, Dennis, A.; Betharia, Swati; Yen, Jui-Hung; Kuo, Ping-Chang; Mistry, Hitesh

subject: Parkinson's disease

department: Pharmacology

abstract: Parkinson’s disease is a neurodegenerative disorder associated with oxidative stress and glutathione depletion. The induction of cellular glutathione levels by exogenous molecules is a promising neuroprotectiveapproach to limit the oxidative damage that characterizes Parkinson’s disease pathophysiology. Dithiolethiones, a class of sulfur-containing heterocyclic molecules, are known to increase cellular levels of glutathione; however, limited information is available regarding the influence of dithiolethione structure on activity. Herein, we report the design, synthesis, and pharmacological evaluation of a further series of dithiolethiones in the SH-SY5Y neuroblastoma cell line.

date: 2016-10-19

type: Faculty Publications

identifier: doi 10.1186/s13065-016-0210-z

citation: Chemistry Central Journal, 2016, vol. 16, issue 64

rights: Open Access

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