Intra-articular interleukin-1 receptorantagonist (IL1-ra) microspheres forposttraumatic osteoarthritis

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Intra-articular interleukin-1 receptorantagonist (IL1-ra) microspheres forposttraumatic osteoarthritis

title: Intra-articular interleukin-1 receptorantagonist (IL1-ra) microspheres forposttraumatic osteoarthritis

creator: Elsaid, Khaled A.; Ubhe, Anand; Shaman, Ziyad; D'Souza, Gerard

subject: Interleukin-1 receptor antagonist

subject: Posttraumatic osteoarthritis

subject: IL1 ra microspheres

department: Pharmacy

abstract: Interleukin-1 receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA).One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide)(PLGA) microspheres reduces IL-1 ra systemic absorption and provides an enhanced anti-PTOA effect.

date: 2016-08-12

type: Faculty Publications

identifier: doi:10.1186/s40634-016-0054-4

citation: Journal of Experimental Orthopaedics, 2016, vol. 3, issue 18

rights: Open Access

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